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I-81 Intersections
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South
- Interstate 40 near Dandridge, Tennessee, northeast of Knoxville
- Interstate 26 between the Tri-Cities: Kingsport, Johnson City, and Bristol, Tennessee
- Interstate 77 in Wytheville, Virginia. They stay joined for about 10 miles (16 km), and go in opposite directions (i.e., this is a wrong-way concurrency, where I-81 North overlaps I-77 South, and vice versa)
- Interstate 64 in Lexington, Virginia. They stay joined until Staunton, Virginia
- Interstate 66 in Middletown, Virginia
- Interstate 70 in Hagerstown, Maryland
- Interstate 76 in Middlesex, Pennsylvania (near Carlisle, Pennsylvania)
- Interstate 83 in Harrisburg, Pennsylvania
- Interstate 78 in Bordnersville, Pennsylvania (near Jonestown, Pennsylvania)
- Interstate 80 in Saint Johns, Pennsylvania (near Hazleton, Pennsylvania)
- Interstate 476 in Dupont, Pennsylvania (near Pittston, Pennsylvania)
- Interstate 84 and Interstate 380 in Dunmore, Pennsylvania (near Scranton, Pennsylvania) Throop Dunmore Interchange
- Interstate 84 and Interstate 380 in Dunmore, Pennsylvania (near Scranton, Pennsylvania) Throop Dunmore Interchange
- Interstate 476 (again) in Clarks Summit, Pennsylvania
- Interstate 88 and future Interstate 86 in Binghamton, New York
- Interstate 88 and future Interstate 86 in Binghamton, New York
- Interstate 690 in downtown Syracuse, New York
- Interstate 90 in North Syracuse, New York
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North
