State Route 10 is an east–west route in southern Alabama. It is the lowest even numbered route in the state that is not an unsigned partner route assigned to a U.S. highway. It is also the only signed state route that extends from the Mississippi state line to the Georgia line. The western terminus of the route is in northwestern Choctaw County near the community of Yantley, where it serves as a continuation of Mississippi Highway 19. The eastern terminus of the route is in Henry County near Shorterville. Once in Georgia, the route is designated as Georgia State Route 37.

SR-10 travels 232 miles (373 km). West of its junction with Interstate 65 in Greenville, the route passes through the Black Belt, traditionally one of the poorer areas of the state. Among the cities and towns the route passes through west of I-65 are Butler and Camden. SR-10 junctions I-65 at Greenville] then passes through Luverne, Troy and Abbeville before reaching the Chattahoochee River at the Georgia state line.

There is a low (10-foot) clearance under a railroad underpass in Greenville.