State Route 163 or SR-163 is a 11.104-mile (17.870 km) state highway that serves as a north-south connection between Mobile and Theodore through Mobile County. SR-163 intersects SR-193 at its southern terminus and US-90 at its northern terminus.

State Route 163 begins at its intersection with SR-193 in Theodore. From its terminus, SR-163 travels in a northeasterly direction on Hollingers Island and passes the Mobile Downtown Airport in route to its intersection with I-10. From its junction with I-10, SR-163 continues in a northerly direction to its northern terminus at Government Street in central Mobile.

The entire route is in Mobile County.