State Route 185 or SR-185 is a 23.129-mile (37.223 km) state highway that serves as an north-south connection between Greenville and Fort Deposit. SR-185 intersects US-31 at both its southern and northern termini.

State Route 185 begins at its intersection with US-31 south of Greenville. From this point, the route continues in a northerly track where it intersects SR-10 just west of the Greenville central business district. SR-185 continues north through the city and intersects both SR-245 and I-65 at Exit 130 prior to leaving the city limits. From this point, the route continues in its northerly track and intersects SR-263 in route to Fort Deposit. SR-185 then reorients in an easterly direction at Fort Deposit and continues its course where it again intersects I-65 (Exit 142) prior to reaching its northern terminus at US-31.