State Route 217 or SR-217 is a 31-mile (50 km) long route that serves as a connection between Eight Mile and Citronelle through western Mobile County.

The southern terminus of SR-217 is located at its intersection with U.S. Highway 45 in Eight Mile. From this point, the route travels in gradual loop towards the northwest before turning towards the northeast in route to its northern terminus with Mobile County Road 21 in Citronelle. Along its route it is known as Lott Road outside Citronelle and as Prine Road and State Street through Citronelle.

The entire route is in Mobile County.