State Route 269 is a 41-mile (66 km) long route that extends northwestward from Birmingham to Jasper. The route runs west of U.S. Highway 78 and roughly parallels that route. Other towns along the route include Maytown, Sylvan Springs, and Parrish.

The southern terminus of SR-269 is at the junction with Interstate 20/Interstate 59 at Exit 120 in western Birmingham. The route leads through the Ensley community along 20th Street, passing by the former U.S. Steel Ensley works. After leaving Birmingham, the route leads through several small communities in western Jefferson County into Walker County. The northern terminus of the route is at its junction with State Route 69 west of Jasper.