State Route 55 is a 47-mile (76 km) long route in the southern part of the state. The southern terminus of the route is at the Florida–Alabama state line, where the route continues as Florida State Road 85. The northern terminus of the route is at a junction with U.S. Highway 31 at McKenzie in southern Butler County.

State Route 55 is a continuation of a route leading northward from Fort Walton Beach and Crestview, Florida. It enters the state at the border town of Florala. As the route heads towards Andalusia, it passes through the Conecuh National Forest.

The route junctions U.S. Highways 29 and 84 at Andalusia, creating a brief wrong-way concurrency, as southbound US-29 shares the same route as northbound State Route 55, as well as westbound US-84. State Route 55 and US-84 are concurrent as they lead northwestwardly from Andalusia. At the small community of River Falls, State Route 55 splits from US-84 and heads northward towards McKenzie, where it reaches its terminus at a junction with U.S. Highway 31. Motorists can then continue towards Montgomery and Birmingham via US-31 and State Route 106, which connects US-31 with Interstate 65.

The route is now a four laned road from its intersection with U.S. 29 just south of Andalusia northward to its termination with U.S. 31 near McKenzie. There is construction ongoing which will extend the four lane portion along a new routing northward following portions of U.S. 31, then to the west of Georgiana to a new intersection a with State Route 106 one mile east of Interstate 65.

This route is increasing in popularity with travelers headed to the Fort Walton/Destin area.[citation needed]