Arkansas Highway 151 (AR 151, Hwy. 151) is a designation for two north–south state highways in Mississippi County, Arkansas. An eastern route of 5.75 miles (9.25 km) runs from Highway 148 north to Highway 18. A second route of 6.65 miles (10.70 km) begins at Highway 18 in Blytheville and runs north to Missouri supplemental route TT (SSR-TT) at the Missouri state line.

The route begins at Highway 148 southeast of Blytheville and runs north near Promised Land to intersect the eastern end of Highway 312 at the Blytheville city limits. Highway 151 continues north into Blytheville over the BNSF railroad tracks to terminate at Highway 18.

Highway 151 begins at Highway 18 (Main Street) in Blytheville and runs north to Gosnell and Arkansas International Airport. The route intersects and forms a concurrency with Highway 181 northwest for 2.04 miles (3.28 km), with Highway 151 splitting north to terminate at Missouri supplemental route TT at the Missouri state line.

Mile markers reset at concurrencies. The entire route is in Mississippi County.