Arkansas Highway 291 is a north–south state highway in Grant County. The route runs 15.71 miles (25.28 km) from Arkansas Highway 46 at Dogwood north to Highway 190 in Tull through Prattsville. The route forms a rare officially designated exception with US 270.

The route begins at Highway 46 at Dogwood near Jenkins' Ferry State Park and runs north. The highway intersects Highway 190 and continues north to Prattsville. In the city, Highway 291 has a rare officially designated exception overlap with US 270 for 0.06 miles (0.097 km). The highway continues north to enter Tull, ending at the southern terminus of Highway 190.

The entire route is in Grant County.