State Route 64, also known as SR 64, is a highway in northern Arizona running from its western terminus in Williams to its junction with U.S. Route 89 in Cameron.

SR 64 serves as the entrance road to the South Rim of Grand Canyon National Park; from Williams to Grand Canyon Village, the road travels in a north-south axis, and from Grand Canyon Village to Cameron, the road travels in an east-west axis. While the road is technically not considered a state route within national park boundaries, as it is maintained there by the National Park Service and not the Arizona Department of Transportation, it is marked as SR 64 in most maps and is considered unbroken for the purposes of numbering in the Arizona state highway system. SR 64 formerly extended past Cameron through to Teec Nos Pos; this designation has been superseded by U.S. Route 160.

From Tusayan to Valle, this road overlaps U.S. Route 180; segments of the road are also known as Navahopi Road, Rim Drive, and Bushmaster Memorial Highway.

SR 64 was first designated as a state highway in 1932 as a route from Williams to the Grand Canyon. In 1935, the highway was extended to the east from the Grand Canyon to US 89. In 1961, the highway was extended further east from US 89 through Tuba City to the New Mexico border. In 1965, the portion from Teec Nos Pos was renumbered to SR 504, which would be renumbered again in 1987 to US 64. In 1965, the section to the east of US 89 became US 164, and would later be renumbered to US 160 in 1969.

The entire route is in Coconino County.