In the U.S. state of California, U.S. Route 95 (US 95) traverses through the far eastern edges of both Riverside and San Bernardino counties. US 95 serves Blythe and Needles and junctions with SR 62 at Vidal Junction.

The route overlaps with two Interstate highways, specifically I-10 near Blythe and I-40 near Needles.

US 95 is part of the California Freeway and Expressway System and is eligible for the State Scenic Highway System. However, it is not a scenic highway as designated by Caltrans.

US 95, running concurrently with I-10, crosses the Colorado River from the state of Arizona and enters the city of Blythe. The highway exits I-10 at Intake Boulevard and turns due north, leaving the city limits. A few miles north, US 95 turns northeast to parallel the Colorado River. The route passes through the Big Maria Mountains and the Riverside Mountains before entering San Bernardino County.

Upon entering San Bernardino County, US 95 turns away from the Colorado River, heading northwest towards Vidal Junction, the junction with SR 62 in the Vidal Valley. The highway continues north through the Chemehuevi Valley and the Chemehuevi Mountains before entering the city of Needles after several miles. After passing the Needles Municipal Airport, US 95 merges onto I-40 westbound and continues through Needles on the freeway. US 95 exits from I-40 west of Needles and continues northwest to Searchlight Junction, where US 95 continues north at the junction with the old routing of US 66. The highway continues north, east of Homer Mountain, to the Nevada state line.

It is also one of four U.S. Highways in California not affected by the 1964 renumbering, the others being U.S. Route 97 and U.S. Route 199 in the northern portion of the state, and U.S. Route 395 which was truncated for other reasons in 1969.

Except where prefixed with a letter, postmiles were measured on the road as it was in 1964, and do not necessarily reflect current mileage. The numbers reset at county lines; the start and end postmiles in each county are given in the county column.