State Highway 52 is a 111 mi (178.6 km)a[›] long state highway in northeastern Colorado.

SH 52 begins near Niwot, running east from its western terminus past US 287 to a diamond interchange with I-25, near the towns of Dacono, Frederick, and Firestone. The highway continues east through interchanges with US 85 in Fort Lupton and I-76 in Hudson. Farther east, the route bends north about 12 miles (19 km) south of Wiggins where it begins its concurrency with I-76, US 6, and US 34 eastward to Fort Morgan where it again turns north and traverses to Raymer, where it ends at SH 14.