Georgia State Route 80 is a predominantly west-east route in east central Georgia.

SR 80 begins just south of Washington at a junction with US 78, SR 10, and SR 17. Just north of Camak, it junctions with I-20. It multiplexes with US 278 Byp. and SR 12 Byp to bypass Warrenton for a short ways, and then continues eastward. In the town of Wrens, the road multiplexes with both SR 17 and SR 88. In Waynesboro, it multiplexes with SR 24 and SR 56, the latter continues with it out of Waynesboro. The roads split northeast of Waynesboro, and then SR 80 heads east to terminate at SR 56 Spur.