U.S. Route 411 is an alternate parallel-highway associated with U.S. Route 11. U.S. 411 extends for about 313 miles (500 km) from U.S. Route 78 in Leeds, Jefferson County, Alabama, to U.S. Highway 25 in Newport, Cocke County, Tennessee. U.S. 411 passes through the northeastern State of Alabama, the northwestern State of Georgia, and the southeastern State of Tennessee. Notable towns and cities along its route include Gadsden, Alabama; Rome, Georgia; Cartersville, Georgia; Cleveland, Tennessee; Maryville, Tennessee, and Newport, Tennessee.

U.S. 411 and U.S. 11 never intersect with one another, though they come very close to one another at Birmingham, Ala., Gadsden, Ala., Cleveland, Tenn., and Maryville, Tenn. U.S. 411 also spends much of its route close to the Interstate Highway System: I-40, I-75, and I-59, though it never intersects I-59.

Most of the distance through which U.S. Highway 411 passes is rural countryside, with no major metropolitan areas directly along its route. However, it does pass relatively near the major cities of Birmingham, Alabama, Chattanooga, Tennessee, and Knoxville, Tennessee. In Sevier County, Tennessee, south of Knoxville, U.S. 411 is used by many tourists as a route to the northern side of the Great Smoky Mountains National Park. U.S. 411 passes about 20 miles (32 km) north of the National Park, but it intersects with U.S. Highway 441, which actually goes through this Park.

U.S. 411 is generally a two-lane highway through the countryside. However, it has long been a four-lane, divided highway connecting Rome, Georgia and Cartersville, Georgia, and it is a multilane highway connecting Cartersville with Interstate 75. Also, for part of its route in the Cartersville area, U.S. 411 shares a four-lane, divided highway with U.S. Highway 41. Furthermore, the Tennessee Department of Transportation is in the process of widening of this highway to four lanes between Maryville and Benton, with the two stretches from Maryville to Madisonville, and Englewood to Delano, Polk County, completed.

Although U.S. 411 has a north–south designation, it contains long stretches that are east–west by the rising and setting sun, and its overall direction is actually from the northeast to the southwest.

US 411 used to join TN-111 for most of its route, but now has been moved to other places.It originally was planned to go through Knoxville and Chattanooga,Tennessee then end in New Orleans,LA.Then ALDOT,MDOT,LDOT and TDOT rejected the plan.Now it terminates in Leeds,Ala and Newport just east of Knoxville in Smoky Mtns National Park