Iowa Highway 130 is a 32-mile (51 km) west–east state highway that traverses northwestern Scott County and eastern Cedar County in Iowa. Its western terminus is at Iowa Highway 38 in Tipton. Its eastern terminus is at Interstate 80 in Davenport.

Iowa Highway 130 begins in Tipton at an intersection with Iowa Highway 38. It proceeds eastward from Tipton and shortly before Bennett, it turns south to enter town. From Bennett, it goes east, turning southeast to go through New Liberty. It continues southeast through Plainview and Maysville and ends at exit 292 along Interstate 80 in Davenport.

Iowa Highway 130 was designated in 1969, along a section of Iowa Highway 150. Until the mid-1970s, Highway 130 extended to US 61 / US 67 along the Davenport riverfront. By the 1980s, a portion of Harrison and Brady Streets had become one-way streets, joining near Vander Veer Park, leading to Iowa 130 to be truncated at the park. When Welcome Way was completed in 1983 and southbound traffic was moved onto Harrison Street, Iowa 130 was truncated further back to Interstate 80.