Kentucky Route 146 (KY 146) is an east–west state highway in northwestern Kentucky.

Its major junctions include:

Louisville: Lyndon Lane, Whipps Mill Road, Evergreen Road, I-265 (exit 30) LaGrange Road,

Crestwood: KY 362, (KY 146 carries KY 362 for 1/4 mile), I-71 (exit 17) KY 146,

LaGrange: KY 53, KY 712,

Henry County: KY 153, KY 157,

There are no low clearances along the entirety of this route and is mostly two lane. This route is rather smartly designed as it carries traffic from Henry County to the East end of Louisville, KY. If travelling Northbound on I-71, exit 28 will route you to KY 146. New Castle is the Eastern terminus for KY 146. Its speed limit is 55 mph (89 km/h) in the rural parts and 35 mph (56 km/h) in the city limits.