Kentucky Route 22 (KY 22) is a 100.991-mile (162.529 km) east–west highway running from the eastern suburbs of Louisville to an unincorporated place called Willow in Bracken County in Northern Kentucky.

Route 22 has a short (0.332 mile) business route in Dry Ridge, an area which has become a commercial center as an I-75 exit.

It begins at US 42 at the city limit of a Louisville suburb called Northfield, Kentucky, and carries the name Brownsboro Road, a local road which begins near Downtown Louisville. It crosses the Kentucky River west of Gratz and terminates at Kentucky Route 10 in Willow.