Maryland Route 210 (MD 210), or Indian Head Highway, is a state highway in Prince George's and Charles counties in Maryland. At its northern end, MD 210 starts from the end of South Capitol Street in Washington, D.C., connecting the U.S. Capitol with Indian Head, Maryland. This state route is accessed from the Capital Beltway by way of Exit 2A (northbound only), Exit 3 (northbound and southbound) and from ramps to and from the southern terminus of Interstate 295. Maryland Route 210 is part of the National Highway System as an arterial route from the Washington, D.C. city line to Maryland Route 228. The Metrobus system provides local bus transportation for various stops along the highway.

Maryland Route 210 begins in Indian Head, Maryland in Charles County along the four-lane, divided, arterial Indian Head Highway, beginning at an intersection with Potomac Avenue within the town. It is located close to the Naval Surface Warfare Center. The section of the highway in Charles County features many direct intersections, with homes and businesses directly fronting the road. The route then heads northeast out of the town into woodland, passing through Potomac Heights and Bryans Road as it exits Charles County.

Once it enters Prince George's County, however, the frequency of intersections greatly decreases; all other access to the highway is restricted largely to frontage roads. The route continues through woodland as it meets the western terminus of MD 228, which features one of only a few continuous-flow intersections (CFI) in the United States, this particular one built in 2000. As the route turns to the north, it passes through several unincorporated communities, such as Accokeek, Fort Washington, and Oxon Hill, with increasingly dense population, including numerous adjacent apartment projects. When the route passes through Forest Heights, it meets an interchange with the Capital Beltway, which provides a direct connection to I-295, and proceeds north to the Washington, D.C. line, at the Eastover shopping center, where it continues into Washington as South Capitol Street.

The highway was originally constructed in 1942, known as the Indian Head Naval Reservation Access Road.

In recent years, development in Charles County and Prince Georges County has prompted the state to start various traffic alleviation projects along the Maryland Route 210 corridor, such as lane widening from the Interstate 295 merge onto the highway to the Charles County line. The northern half of the highway from Interstate 295 to Maryland Route 228 is designated and funded for road construction under the Woodrow Wilson Bridge project, including replacing every at-grade intersection with controlled-access ramp interchanges, with the overall goal of decreasing constant bottlenecks in the area.

In the early morning hours of February 16, 2008, eight spectators of a drag race died and at least four others were injured when a vehicle that was involved in a second, separate race ran through a crowd, which was standing in the middle of Route 210 in Accokeek.