Route 33 is a highway in western Missouri. Its northern terminus is at Route 6 in Maysville; its southern terminus is at Route 291 in the city of Liberty.

Route 33 is one of the original 1922 state highways. Its northern terminus was at Route 8 (now U.S. Route 136 in southern DeKalb County. At Plattsburg, it turned west (modern Route 116 and then south on current U.S. Route 169.

A branch route, Route 33A, left the former alignment and connected it with Lathrop. This branch is now part of the highway itself.