North Carolina Highway 146 (NC 146) is a short east/west state highway in western North Carolina and lies entirely in Buncombe County, south of the city of Asheville.

North Carolina Highway 146 begins its western end at North Carolina Highway 191 in the community of Avery Creek, a census-designated place (CDP) south of Asheville. NC 146 travels east and at just over 1.5 miles, intersects Interstate 26/U.S. 74 at Exit 37. Passing exit 37, NC 146 passes north of Lake Julian and Julian Lake Park before nearing its eastern end. At 3.51 miles, NC 146 reaches its eastern end at U.S. Route 25 in Skyland. NC 146 is named Long Shoals Road for its entire length.

The current routing of North Carolina Highway 146 was designated around 1991 as a renumbering of North Carolina Highway 280. NC 280 was rerouted at NC 191 to head directly east to U.S. Route 25. As a result, the former routing of NC 280 from NC 191 to Skyland became NC 146.

The entire route is in Buncombe County.