North Carolina Highway 180 (NC 180) is a primary state highway in the state of North Carolina. The highway serves as a bypass east of Shelby.

NC 180 is a two-lane rural highway that traverses 12 miles (19 km) from NC 18, near the South Carolina state line, through the town of Patterson Springs, where it meets briefly with NC 226. Continuing north, it passes through Eastern Shelby, crossing US 74, then heads back to NC 18, north of Shelby.

Established in 1952, as a mostly new primary route around Shelby, and has not changed since. The first NC 180 was from 1932-1952, connecting the communities of Polkville to Fallston; it was renumbered as an extenstion of NC 182.

The entire route is in Cleveland County.