County Route 501, abbreviated CR 501, is a county highway in New Jersey in two sections spanning Middlesex, Hudson and Bergen Counties. The southern section runs from South Plainfield to Perth Amboy, the northern section runs from Bayonne to Rockleigh, and the two sections are connected by New York State Route 440 across Staten Island.

The New Jersey Department of Transportation lists CR 501 as a single highway with a length of 53.07 miles (85.41 km), which includes both sections as well as the connection along NY-440.

The Southern terminus of County Route 501 is at CR 529 in South Plainfield. From there, the route heads east to Metuchen, where it has a short concurrency with Route 27. It then continues east, crossing the Garden State Parkway between Exits 127 and 129 in Woodbridge, following concurrencies with Route 184 and Route 440 to the southern section's eastern terminus at the Outerbridge Crossing.

The northern section of CR 501 starts at the Route 440/Bayonne Bridge junction in Bayonne, making its way north to Route 63 in North Bergen. The highway crosses Route 139 to the Holland Tunnel and Route 495 to the Lincoln Tunnel.

At its junction with Route 63 in North Bergen, CR 501 begins a concurrency with Route 63 into Bergen County, while John F. Kennedy Boulevard loops around the northern end and heads south to Guttenberg, West New York and Weehawken.

Major points on CR 501/Kennedy Boulevard include Marist High School, New Jersey City University, Saint Peter's University, Journal Square, Union City High School, and four County parks: Stephen R. Gregg (Bayonne) Park and Mercer Park in Bayonne, Lincoln Park in Jersey City and James J. Braddock (North Hudson) Park in North Bergen.

Immediately northeast of Journal Square, CR 501/Kennedy Boulevard crosses over Port Authority Trans-Hudson (PATH) railroad tracks on an open-spandrel concrete arch bridge completed in 1926. The bridge is a pared-down version of a more ambitious elevated plaza scheme proposed by consulting engineer Abraham Burton Cohen. Cohen's office constructed a model using slot cars to demonstrate traffic flow through the plaza.

Prior to being renamed in honor of John F. Kennedy in the 1960s, the street was known as Hudson Boulevard. While there was discussion of building a county long road as early as the 1870s, parts of Hudson County Boulevard were officially opened in 1896. By 1913 it was completed, and considered to be fine for "motoring", and included Boulevard East. Taken as a single road, the circuitous route of west and east sections of the entire boulevard runs from the southern tip of the county at Bergen Point to its northern border with Bergen County and south again to the Hoboken city line.

The Boulevard was named the fifth most dangerous road for pedestrians in New Jersey, and the most dangerous road in Hudson County for pedestrians in a February 2011 report by the non-profit Tri-State Transportation Campaign. The road was the location of six pedestrian fatalities between 2007 and 2009, which account for a little more than a fifth of Hudson County's 29 pedestrian deaths in the three-year period. County officials have expressed interest in building a pedestrian bridge that crosses Kennedy Boulevard at 32nd Street, at the Union City-North Bergen border at least since 2001. The two cities contracted a company to build the bridge for just over $4 million in November 2010. Construction plans began in May 2011, and field work began later that August.

In Bergen County, CR 501 leaves its concurrency with Route 63 in Palisades Park, using Central Boluevard to connect to the US 1/9/46 concurrency and Route 93. It is then concurrent with Route 93 until it reaches that route's northern terminus at Route 4 in Englewood. CR 501 continues north from this junction through Rockleigh, crossing the New York State Line and becoming New York State Route 340.