New York State Route 222 (NY 222) is an east–west state highway in central New York in the United States. It runs from an intersection with NY 38 in the village of Groton in northeastern Tompkins County to a junction with the conjoined routes of U.S. Route 11, NY 13, and NY 41 in the city of Cortland in western Cortland County. NY 222 passes through the town of Cortlandville, where it intersects NY 281 and serves Cortland County–Chase Field Airport. The road was acquired by the state of New York in the early 20th century and designated NY 222 as part of the 1930 renumbering of state highways in New York.

NY 222 begins at an intersection with NY 38 (Main and Cayuga streets) in the village of Groton. The route proceeds east along East Cortland Street, a two-lane asphalt residential street through Groton. A short distance after crossing into the town of Groton, NY 222 changes monikers to Cortland Road and becoming a two-lane farm road. Some businesses appear on NY 222 as it crosses Lick Street. Several blocks later it becomes a residential and rural mix, soon intersecting with County Route 102 (CR 102; Salt Road). The surroundings remain for a distance, crossing an intersection with CR 103A (Champlin Road) before darting northeast into an intersection with CR 180 (Lafayette Road).

Paralleling Fall Creek, NY 222 proceeds northeast through Groton, making a large bend around the side of a hill. Along this stretch, CR 103 (Groton City Road) intersects. Once proceeding southeast along the hillside, NY 222 remains rural for several blocks, crossing the county line from Tompkins County to Cortland County. Now in the town of Cortlandville, NY 222 drops the Cortland Road moniker, making a gradual bend to the northeast at Old Groton Road. Now with the moniker of Groton Road, the route proceeds southeast into an intersection with CR 119 (Sears Road). At this intersection, Groton Road drops as a moniker again, and NY 222 proceeding to the northeast as a two-lane residential road.

For several blocks, homes surround NY 222, until Cortland County–Chase Field Airport becomes accessible on the eastbound side. Proceeding northeast, NY 222 parallels the airport, passing the entrance and entering an intersection with NY 281 (West Road). At this intersection, NY 222 becomes a two-lane commercial boulevard through Cortlandville, passing several strip malls until crossing back into a residential section of the city of Cortland. Now named Groton Avenue, NY 222 winds eastward through several blocks of homes, passing north of the State University of New York at Cortland. Once becoming a commercial street again, NY 222 intersects with NY 41 and US 11 (Main Street). At this intersection, NY 222, NY 41 and US 11 become concurrent for a city block as Clinton Avenue, intersecting with NY 13, where the NY 222 designation terminates. NY 13 northbound continues east along Clinton Avenue while NY 13 southbound heads south along Church Street on an overlap with US 11 and NY 41.

The east–west highway connecting the village of Groton to the city of Cortland was originally improved to state highway standards as part of three separate projects in the early 20th century. On July 10, 1906, the first project was let to rebuild the section between the Cortland city line and Highland Road, a north–south road west of what is now Cortland County–Chase Field Airport. The road was added to the state highway system on October 11, 1907, as unsigned State Highway 446 (SH 446). A contract to improve the part of the Groton–Cortland road leading west from Highland Road to the Tompkins County line was awarded on April 29, 1912; this segment was accepted into the state highway system on January 8, 1913, as SH 996.

In Tompkins County, the road was reconstructed as part of a project contracted out on August 24, 1916. Work on the highway was completed in the early-to-mid-1920s, and the improved road was added to the state highway system as SH 1433. The Groton–Cortland state highway did not have a posted route number until the 1930 renumbering of state highways in New York, when hundreds of state-maintained highways were assigned a designation for the first time. SH 446, SH 996, and SH 1433 were collectively designated as NY 222, which continued east into downtown Cortland by way of locally maintained streets. The alignment of NY 222 has not been changed since that time.