New York State Route 442 (NY 442) is a state highway located within the town of Peru in Clinton County, New York, in the United States. It is an east–west highway that connects the hamlet of Peru with the Adirondack Northway (Interstate 87). The western terminus of the route is at an intersection with NY 22 in the hamlet of Peru. Its eastern terminus is at a junction with US 9 near the shore of Lake Champlain. NY 442 was assigned in the early 1970s as a town-maintained, state-numbered route. It became state-maintained in 1988.

NY 442 begins at an intersection with NY 22 in the hamlet of Peru within the town of the same name. The route heads eastward, intersecting with local roads before leaving Peru. For a brief distance, NY 442 and 22 parallel, but 22 turns to the north while NY 442 continues eastward. Soon after the intersection with Dashnaw Road, NY 442 connects with the Adirondack Northway (I-87) by way of an interchange. The highway heads through Laphams Mills, a small hamlet and terminates at U.S. Route 9 (the Lakes to Locks Passage), just east of Ausable Point.

NY 442 was assigned to its current alignment in the early 1970s. Although it was signed as a state route, NY 442 was initially maintained by the town of Peru. On September 1, 1988, ownership and maintenance of NY 442 was transferred from the town to the state of New York as part of a highway maintenance swap between the town, the state, and Clinton County. In exchange, the state ceded maintenance of NY 22 north of US 11 in Mooers to the county.

The entire route is in Peru, Clinton County.