State Route 606 (SR 606, OH 606) is a north–south state highway in the northeastern quadrant of the U.S. state of Ohio. The southern terminus of State Route 606 is at a T-intersection with State Route 3 approximately 4.50 miles (7.24 km) northeast of Medina. The highway's northern terminus is at another T-intersection, this time with the State Route 94/State Route 303 duplex nearly 3.25 miles (5.23 km) west of Richfield.

State Route 606, which was established in the late 1930s, is a two-lane route located in northeastern Medina County, with the vast majority of the highway running through Hinckley Township. The highway serves the popular Hinckley Reservation, home to the annual "Buzzard Day," which marks the annual arrival of large numbers of buzzards to the area on March 15 of every year.

All of State Route 606 is situated within the northeastern quadrant of Medina County. This state highway is not included as a component of the National Highway System, a network of highways important to the economy, mobility and defense of the nation.

State Route 606 commences at a T-intersection with State Route 3 just south of the northern boundary of Granger Township approximately 4.50 miles (7.24 km) northeast of Medina, and 1 mile (1.6 km) northeast of the State Route 3 interchange off of Interstate 71, its Exit 222. The highway immediately crosses into Hinckley Township as it departs to the northeast from the State Route 3 intersection. Starting out, State Route 606 is bounded by open fields on the southeast side and houses on the northwest side. The highway crosses Stony Hill Road, then passes amidst a stretch where both sides of the roadway feature a mix of residences and woods, with a little bit of open space mixed in. State Route 606 bends east and intersects State Route 3 again, this time joined by State Route 94. State Route 606 crosses the duplex, and then curves back to the northeast. The area the route travels through is now more heavily wooded than previously, but a number of homes continue to dot the landscape. It curves to the east-northeast, passes Kellogg Road, then turns back to the northeast as it passes by the Hinckley Reservation. After intersecting Bellus Road, State Route 606 bends to the north, and then to the northwest, prior to arriving at its endpoint at a T-intersection with the State Route 94/State Route 303 duplex about 3.25 miles (5.23 km) west of Richfield.

State Route 606 made its debut in 1937. The State Route 606 designation was applied to the same stretch of highway through northeastern Medina County that it utilizes to this day. There have been no changes of major significance to the routing of this state highway since its inception.

The entire route is in Medina County.