State Route 744 (SR 744, OH 744) is an east–west state highway in southwestern Ohio, a U.S. state. The western terminus of State Route 744 is at its junction with U.S. Route 127 a distance of 1 mile (1.6 km) northwest of Somerville. The eastern terminus of the state route is at a T-intersection with State Route 122 approximately 1.50 miles (2.41 km) east of the village of Jacksonburg.

State Route 744 travels through southern Preble County and northern Butler County. No stretch of the highway is a part of the National Highway System.

When it debuted in 1937, State Route 744 ran from its intersection where it splits off of Main Street in Somerville to its current eastern terminus at State Route 122 east of Jacksonburg. At the time, Main Street through Somerville was the routing of U.S. Route 127. By 1961, U.S. Route 127 was routed onto a new alignment west of Somerville, resulting in an extension of State Route 744. From its previous western terminus, State Route 744 was routed north along the former alignment of U.S. Route 127 to the County Road 30 intersection north of Somerville, and then west to the now-current U.S. Route 127 routing, which marks the current western endpoint of the state highway.