Arkansas Highway 220 is a designation for two state highways in west Arkansas. The southern segment of 7.89 miles (12.70 km) runs from Oklahoma State Highway 101 near Uniontown to AR 59. A northern segment of 17.04 miles (27.42 km) runs from AR 59 north to AR 170 in Devil's Den State Park. The route is not paved within Devil's Den State Park, and is the only Arkansas state highway that remains unpaved. The route will likely never be paved due to the prohibitive cost of using paving machines in the rough terrain, and the potential damage to wildlife that inhabit the state park when paving the route.

AR 220 begins at SH 101 at the Oklahoma state line and runs as the Uniontown Highway to meet AR 59 south of Cedarville.

The route begins again 4 miles (6.4 km) north, when the route turns northeast, ending at AR 170 in Devil's Den State Park.

The entire route is in Crawford County.