In the U.S. state of Texas, U.S. Highway 83, dedicated as the Texas Vietnam Veterans Memorial Highway, is a U.S. Highway that begins at US 77 in Brownsville and follows the Rio Grande to Laredo, then heads north through Abilene to the Oklahoma border north of Perryton, the seat of Ochiltree County. It is the longest north-south highway in Texas, and the second longest overall (behind Interstate 10).

US 83's southern terminus is at a concurrency with US 77 on the south side of Brownsville at the US/Mexico border. It remains co-signed with US 77 until Harlingen, where US 77 makes a sharp turn northward and US 83 maintains a westerly route to McAllen, Texas. From McAllen, the highway roughly parallels the Rio Grande until Laredo where it makes a northwesterly turn toward Carrizo Springs, the seat of Dimmit County. Speed Limit on US 83 is briefly 75 mph through Dimmit County.

Merging with I-35 just south of downtown, US 83 remains co-signed with the interstate until an exit at Botines, Texas. From there, it continues northward, intersecting with I-10 just south of Junction. US 83 is co-signed with I-10 for approximately 8 miles (13 km), turning northward and leaving I-10 at the Kimble County Airport.

After continuing northward through several rural western Texas towns, US 83 then merges with US 84 east of Tuscola, where it makes a sharp turn back to the north. US 83/84 remains a co-signed route until Abilene, where US 84 turns to the northwest and US 83 remains northbound, merging with US 277 on the west side of the city. US 83/277 remains a co-signed route until approximately 2 miles (3.2 km) north of Anson, where US 277 turns northeast, and US 83, northwest.

After merging with US 380 in Aspermont and briefly sharing a route, US 83 continues northward, merging with US 62 in Paducah. US 83/62 continues as a co-signed route until approximately 15 miles (24 km) south of Wellington, where US 62 makes a sharp turn eastward, leaving US 83 to continue northward, where it crosses into Oklahoma approximately 6 miles (9.7 km) north of Perryton.