Pennsylvania Route 114 (PA 114) is a 19-mile (31 km) long state highway located in Cumberland and York counties in Pennsylvania. The western terminus is at PA 944 in Wertzville. The eastern terminus is at SR 1003 at the Capital City Airport.

PA 114 begins at an intersection with PA 944 in Silver Spring Township, Cumberland County, heading south on two-lane undivided Conodoguinet Parkway. The road heads through areas of farms and woods, reaching an interchange with I-81, where it becomes a four-lane divided highway. From this point, the route heads southeast and crosses the Conodoguinet Creek, continuing south into business areas and intersecting US 11. Past this intersection, PA 114 becomes two-lane undivided Hogestown Road and runs through agricultural areas with some housing developments, curving southeast. The road heads through residential areas as it turns south and comes into Mechanicsburg, with the road name becoming North York Street. Here, the route passes industrial areas to the west and homes to the east. PA 114 enters residential and business areas as it crosses a Norfolk Southern railroad line and intersects PA 641, turning east to form a concurrency with that route on West Main Street. The road runs through the commercial downtown, with PA 114 splitting from PA 641 by turning south onto South Market Street.

The route continues past several homes, crossing into Upper Allen Township. The road briefly becomes the border between Upper Allen Township to the west and Mechanicsburg to the east before fully entering Upper Allen Township again and running through areas of farmland and housing developments, crossing over I-76 (Pennsylvania Turnpike). PA 114 continues south through residential subdivisions with some commercial establishments, reaching an interchange with the US 15 freeway. The route continues southeast past more suburban development, turning east onto East Lisburn Road in Bowmansdale. PA 114 heads north-northeast into agricultural areas, turning southeast to pass under a Norfolk Southern railroad line before resuming north-northeast. The road continues east through a mix of farmland and woodland with some homes, crossing into Lower Allen Township and running through the residential community of Lisburn on Main Street.

PA 114 crosses the Yellow Breeches Creek into Fairview Township in York County and becomes Cedars Road, heading through rural areas with a few residences. The route intersects PA 382 and turns to the north onto Lewisberry Road, curving northeast into forested areas with some homes. PA 114 comes to an intersection with PA 262 in Bunches and turns northwest to continue along Lewisberry Road. The road passes through more wooded areas before turning north and running through a mix of fields and residential development. The route curves northeast near Fair Acres and heads through more rural residential areas as it comes to an interchange with I-83. Past this, the route runs through woods and crosses under the Pennsylvania Turnpike. PA 114 runs through more residential areas prior to ending at SR 1003 (Old York Road) near Capital City Airport.