Pennsylvania Route 212 is a state highway in Bucks County, Pennsylvania. The route runs from Pennsylvania Route 313 in Quakertown northeast to Pennsylvania Route 611 in Durham Township, just south of the borough of Riegelsville.

Pennsylvania Route 212 starts out in a northerly direction from PA 313 in Quakertown on Hellertown Avenue. The road swings east and becomes known as Tohickon Avenue. It then turns north again and exits Quakertown as Richlandtown Pike. It passes through the borough of Richlandtown on Main Street before exiting town on Church Street. Pennsylvania Route 212 becomes known as Church Road past Richlandtown. It enters Springfield Township and it becomes known as Quakertown Road. It then merges onto Old Bethlehem Road before splitting from it just short of the junction with Pennsylvania Route 412. Old Bethlehem Road continues north to connect with northbound PA 412. Pennsylvania Route 212 continues east and then joins with Pennsylvania Route 412 and the two routes pass through the village of Springtown on Main Street. PA 412 eventually turns south and Pennsylvania Route 212 continues east toward Durham Township, where it ends at Pennsylvania Route 611 along the Delaware River south of Riegelsville.

The entire route is in Bucks County.