Pennsylvania Route 374 (designated by the Pennsylvania Department of Transportation as PA 374) is an 17.7-mile (28.5 km) long state highway located in Susquehanna County in Pennsylvania. The western terminus is at PA 92 in Lenox Township. The eastern terminus is at Route 171 / Route 371 near Union Dale in Herrick Township.

PA 374 begins at an intersection with PA 92 in Lenox Township, heading east on a two-lane undivided road. The route crosses the Tunkhannock Creek and heads into farmland before heading into forested areas to the north of the East Branch Tunkhannock Creek and intersecting the northern terminus of PA 407. The road continues through forests with some homes and heads across the creek. PA 374 runs south of the East Branch Tunkhannock Creek and comes to an interchange with I-81. Past this interchange, the road heads northeast through more wooded areas with some residences, crossing into Clifford Township. The route runs through areas of fields and woods with a few homes, coming to an intersection with PA 106 in Royal. At this point, PA 374 turns north for a concurrency with PA 106, passing through a mix of farmland and woodland with occasional residences. In West Clifford, PA 374 splits from PA 106 by heading northeast on Brooklyn Street, passing through more rural areas. The route turns north onto an unnamed road and passes through forests before turning northeast and heading through woodland with some farm fields and homes. PA 374 passes through a corner of Gibson Township before entering Herrick Township and turning east onto Brace Road.

The road runs through more farms and woods with some residences, passing to the north of Elk Mountain Ski Area. The route turns north onto Lyon Street and passing through more rural areas. PA 374 turns east onto Old Newburg Turnpike in Dimock Corners and passes through more agricultural and wooded areas with homes, heading through Herrick Center before ending at PA 171. East of here, the road continues as PA 371.

The entire route is in Susquehanna County.