Pennsylvania Route 390 (PA 390) is an 25-mile (40 km) long state highway located in Monroe, and Pike counties in Pennsylvania. The southern terminus is at PA 940 near Paradise Township. The major routes that PA 390 joins are PA 191, PA 447, and I-84. The northern terminus is at PA 507 in Tafton View.

Along the route, PA 390 joins PA 191 for about 2.5 miles before the split in Mountainhome. North of PA 447 is Skytop, which then leads into the scenic part of the route. PA 390 passes Promised Land State Park, a small, but reasonable sized state park. Then, PA 390 passes the former Tanglewood Ski Area, now a winery and Italian restaurant.

PA 390 begins at an intersection with PA 940 in Paradise Township, Monroe County, heading northeast on a two-lane undivided road. The route heads through forested areas with some homes, reaching an intersection with PA 191. At this point, PA 390 heads north concurrent with PA 191, running through more dense forests with some development and crossing into Barrett Township. The road turns north-northeast and passes over a Delaware–Lackawanna Railroad line before heading through the community of Cresco. The two routes continue into the residential and commercial community of Mountainhome, where PA 191 splits to the north and PA 390 becomes Peterson Road. The road continues through more wooded areas with some homes as an unnamed road, crossing the Middle Branch Brodhead Creek and intersecting PA 447 in Canadensis. The route becomes Krummel Hill Road and runs through more dense forests with some residential development, heading through Skytop before passing to the east of Mountain Lake and winding north.

PA 390 enters Greene Township in Pike County and becomes Promised Land Road, heading north and northwest through dense forested areas. The road heads north through Roemersville before turning east and northeast as it runs through more forests with some private residential developments. The route heads into Promised Land State Park and turns north, passing to the west of Promised Land Lake and crossing into Palmyra Township. PA 390 leaves the state park and heads into the Delaware State Forest as Fairview Lake Road, continuing north to an interchange with I-84. Past this interchange, the road leaves the state forest and continues through more forested areas, curving to the northeast. The route crosses into Blooming Grove Township and turns to the north as an unnamed road, heading back into Palmyra Township and passing to the east of Fairview Lake before running through Tafton. PA 390 runs through more dense forests with private residential developments, ending at an intersection with PA 507 near the community of Tafton View to the southeast of Lake Wallenpaupack.