Pennsylvania Route 433 (PA 433) is an 9-mile (14 km) long state highway located in Franklin county in Pennsylvania. The southern terminus is at US 11 near Red Bridge. The northern terminus is at PA 997 in Lurgan Township.

PA 433 begins at an intersection with US 11 in Greene Township, heading north on two-lane undivided Sunset Pike. The road passes through agricultural areas with some industrial development, crossing a CSX railroad line. At this point, the route passes to the east of the Letterkenny Army Depot. PA 433 comes to a junction with PA 997 and turns northeast onto Rowe Run Road, heading into open farm fields. The road continues into Southampton Township and passes through the community of Pinola, turning to the north into farmland with some woods. The road curves to the northwest and heads into Orrstown, where it passes homes and crosses PA 533. PA 443 crosses back into Southampton Township before crossing the Conodoguinet Creek into Lurgan Township and becoming Tanyard Hill Road. The road continues through farmland with some woods and homes before reaching its northern terminus at another intersection with PA 997.

The entire route is in Franklin County.