Pennsylvania Route 533 (PA 533) is an 22-mile (35 km) long state highway located in Franklin and Cumberland counties in Pennsylvania. The western terminus is at Mountain Road in Letterkenny Township. The eastern terminus is at PA 233 in Newville.

PA 533 begins at an intersection with SR 4004 (Mountain Road/Valley Road) in the community of Upper Strasburg in Letterkenny Township, Franklin County, heading east on two-lane undivided Upper Strasburg Road. West of here, the road becomes Valley Road while Mountain Road heads to the north. The route runs east past homes before heading into open farmland with a few residences, forming the northern boundary of the Letterkenny Army Depot. In the community of Pleasant Hall, PA 533 crosses PA 997. Past this intersecyion, the route becomes Orrstown Road and heads away from the Letterkenny Army Depot, continuing through more agricultural areas with occasional homes. The road curves northeast and heads into Southampton Township and passes through more rural areas before entering Orrstown. Here, PA 533 is lined with homes and intersects PA 433. The route heads back into Southampton Township and runs through more farmland with a few residences, turning to the east. Farther east, the road heads into Shippensburg and becomes North Morris Street, passing several homes.

PA 533 becomes the border between Cumberland County to the north and Franklin County to the south and runs through more residential areas of Shippensburg, intersecting US 11. At this point, the route turns northeast to form a concurrency with US 11 on West King Street, fully entering Cumberland County. The road heads into the commercial downtown, reaching an intersection with PA 696. Here, PA 696 joins US 11/PA 533 and runs through more of the downtown. PA 696 splits to the north and US 11/PA 533 becomes East King Street, leaving the downtown and heading into more residential areas. Upon intersecting the western terminus of PA 174, the road heads into Shippensburg Township and passes a few businesses before heading into a mix of farmland and woodland with a few homes. US 11/PA 533 continues into Southampton Township and becomes Ritner Highway. PA 533 splits from US 11 by heading northwest onto Newville Road. The route curves to the northeast and runs through open agricultural areas with some residences and woods. The road passes to the east of a quarry before it continues into North Newton Township and continues through agricultural surroundings. At the Oakville Road junction, PA 533 becomes Shippensburg Road and runs through more rural areas. The road continues into Newville and becomes Fairfield Avenue, turning east into residential areas. PA 533 becomes Vine Street at the West Big Spring Avenue intersection and continues east to its terminus at PA 233.