South Carolina Highway 160 is a primary state highway in the U.S. state of South Carolina. It runs from North Carolina state line, through the towns of Tega Cay and Fort Mill, ending in Indian Land.

SC 160 begins at the North Carolina state line near the Steele Creek area of Charlotte, North Carolina. Going southeast, it crosses Gold Hill Road in Tega Cay before entering Fort Mill. The highway goes through the downtown area of Fort Mill, connecting briefly with US 21 Business. Continuing east, it ends at US 521 in Indian Land. The entire route is a two-lane highway, which various sections known for heavy traffic congestion during rush hour.

Though the highway is commonly known as "SC 160" or "Highway 160" throughout the state, the highway does have other known names it uses locally in areas.

Established in 1942 as a renumbering of the second SC 211. The route has changed little since.

Old signs along highway use a north–south designation; newer signs designate the highway as east–west.

Currently, there is one truck route for South Carolina Highway 160:

Truck route follows US 21 north to SC 460 (Springfield Parkway), where it goes southeast back to SC 160. The route keeps truckers off 2.7 miles (4.3 km) of downtown Fort Mill.