State Route 131 is a south-to-north highway in the U.S. state of Tennessee that is 67 miles (108 km) long. It is designated as a secondary route.

State Route 131 begins in Knoxville at Kingston Pike (State Route 1 and U.S. Route 70/U.S. Route 11); it ends in Treadway (Hancock County) at State Route 31.

Local names for the roads followed by portions of the route in Knox County are Lovell Road, Ball Camp-Byington Road, Beaver Ridge Road, Emory Road, and Tazewell Pike.

State Route 131 traverses the counties shown in the table below.