State Highway 351 or SH 351 is a Texas state highway that runs from Abilene northeast to an intersection with U.S. Highway 180 west of Albany. The route was designated in 1943 as a replacement for U.S. Highway 80A.

SH 351 begins at an intersection with U.S. Highway 83 Business (Treadaway Boulevard) in Abilene The highway heads east through Abilene along Ambler Avenue. It curves to the northeast prior to a diamond interchange with Interstate 20. The highway heads northeast as it leaves the Abilene city limits on its way to intersections with FM 1082, FM 604 and FM 3522. It continues to the northeast to its eastern terminus at a concurrent US 180 and SH 6.