Wyoming Highway 312 is north–south Wyoming State Road located in central Platte County, Wyoming that runs from Wyoming Highway 34 to I-25 BUS/US 87 BUS in Wheatland.

Wyoming Highway 312 begins at its south end at Wyoming Highway 34, south-southeast of Wheatland, and travels north towards Wheatland. At about 6.2 miles (10.0 km), WYO 312 enters the city limits of Wheatland, and is named South Street, as the route turns east to head to an end at I-25 BUS/US 87 BUS and the eastern terminus of Wyoming Highway 310.

Wyoming Highway 312 is the original path that Wyoming Highway 34 used to take into Wheatland before it was realigned to go directly to the Interstate 25.

The entire route is in Platte County.