Wyoming Highway 375 is a short 0.95-mile (1.5 km) spur route in Sweetwater County that serves the town of Granger.

Wyoming Highway 375 begins in the small town of Granger at 3rd Street and Pine Street. WYO 375 travels 0.95 miles, paralleling Blacks Fork, till it reaches U.S. Route 30 where it ends on the northeast edge of Granger. Granger and WYO 375 are located northwest of the Interstate 80/U.S. Route 30 and Wyoming Highway 374 junction.

The entire route is in Granger, Sweetwater County.