The George Parks Highway (numbered Interstate A-4 and Alaska Route 3), usually called simply the Parks Highway, runs 323 miles (520 km) from the Glenn Highway 35 miles (56 km) north of Anchorage to Fairbanks in the Alaska Interior. The highway, originally known as the Anchorage-Fairbanks Highway, was completed in 1971, and given its current name in 1975.

The highway, which mostly parallels the Alaska Railroad, is one of the most important roads in Alaska. It is the main route between Anchorage and Fairbanks (Alaska's two largest metropolitan areas), the principal access to Denali National Park and Preserve and Denali State Park, and the main highway in the Matanuska-Susitna Valley.

It is a common misconception that the name "Parks Highway" comes from the road's proximity to the Denali state and national parks; it is in fact in honor of George Alexander Parks, governor of the Territory of Alaska from 1925 to 1933. However, the aptness of the name was recognized when it was chosen.

Mileposts along the Parks Highway do not begin with 0 (zero). Instead, they begin with Mile 35 (km 56), continuing the milepost numbering of the Glenn Highway where the two highways intersect near Palmer. The 0 (zero) mile marker for the Glenn Highway is at its terminus in downtown Anchorage at the intersection of East 5th Avenue and Gambell Street. Thus mileposts along the Parks Highway reflect distance from Anchorage, which is not actually on the Parks Highway.

There are two sections of the highway that are built to freeway standards. These include an area near the highway's intersection with the Glenn Highway in Palmer and a stretch known as the Robert J. Mitchell Expressway in Fairbanks leading to the highway's junction with the Richardson Highway (AK 2).

Former Alaska governor Tony Knowles criticized Sarah Palin for supporting the Knik Arm Bridge, the Gravina Island Bridge, and a road north out of Juneau instead of rebuilding the Parks Highway. However, the Ketchikan Daily News noted that, of the gubernatorial candidates, "Only Palin is consistent in support all of the projects."

In the "Mile" column, the first number is the actual mileage of the Parks Highway, and the second mile is based on the mileposts along the highway itself. All exits are unnumbered.