State Route 25 is a long and relatively rural State highway in the State of Alabama. From US-78 in Leeds northeast to its terminus at the State of Georgia line, SR-25 is the unsigned partner route of U.S. Highway 411. The southwestern terminus of State Route 25 is at its junction with State Route 5 near Pine Hill in Wilcox County.

For the first 50 miles (80 km) of its route, State Highway 25 travels in a north–south direction. This highway begins by traveling through rural areas of west-central Alabama, connecting numerous small towns in the Black Belt region of Alabama. From Greensboro to its terminus, the orientation of Highway 25 is in a general northeasterly/ southwesterly direction. As this highway begins its northeastward path, it passes through rural areas, villages, and small towns, skirting the southern area of the Birmingham Metropolitan Area in Shelby County.

State Highway 25 traverses one of the higher peaks in the Birmingham area, Double Oak Mountain, connecting the Coosa and Cahaba River valleys. The roadway that was constructed between 1914 and 1921 with support from Buffalo Rock founder Sidney Word Lee, who owned a 3,000-acre camp in Calcis. There is also a railroad line that runs parallel with Highway 25 between Vincent and Leeds that tunnels though Double Oak Mountain below the highway.

The 19-mile (31 km) stretch of highway 25 between Vincent and Leeds is popular with motorcyclists and other outdoor enthusiasts. This road is off limits to heavy trucks except for local deliveries due to a large number of sharp curves, blind entrances and exits, and a narrow, elevated roadway. The small communities of Vandiver, Sterrett, Calcis, and Dunnavant straddle the highway in this area. The exclusive and private Shoal Creek Golf and Country Club, home of the 1984 and 1990 PGA Championships is located on Shelby County Route 41 not far from its intersection with SR-25.