U.S. Route 67 is a U.S. highway running from Presidio, Texas northeast to Sabula, Iowa. In the U.S. state of Arkansas, the route runs 279.15 miles (449.25 km) from the Texas border in Texarkana northeast to the Missouri border near Corning. The route passes through several cities and towns, including Hope, Benton, Little Rock, Beebe, Walnut Ridge, and Pocahontas. US 67 runs concurrent with several highways in Arkansas including Interstate 30 (I-30) between Benton and Little Rock, U.S. Route 64 in Arkansas through White County, U.S. Route 63 in Hoxie and Walnut Ridge, and with U.S. Route 62 in northeast Arkansas.

U.S. Route 67 runs parallel to Interstate 30 from Texarkana to Benton, where it then runs concurrent with I-30 to North Little Rock. It then runs east, concurrent with I-40, for about 2 miles (3.2 km) then branches off to the northeast as a freeway to near Swifton. Temporarily, US 67 travels west for about 6 miles (9.7 km) along Highway 226 at the end of the freeway to its old 2-lane alignment, where it continues north toward Hoxie. Just south of Hoxie, US 67 is routed east along the US 63 bypass for a short distance, then north on a short section of freeway bypassing Hoxie and Walnut Ridge. This section of freeway will eventually be connected to the interstate-style freeway that currently ends at Arkansas Highway 226. It is currently under construction and will open in the next two to three years.

Just north of US-412, the freeway ends at a large, partially complete interchange, and US-67 becomes a five-lane undivided highway north to Pocahontas. From Pocahontas, US-67 turns northeasterly as a two-lane highway to Corning with a concurrency with US 62, then turns north again and crosses into Missouri.

The southwest-northeast bisector of Arkansas has always been an integral motor route. Prior to designation as US 67, the route was known as the Southwest Trail, an old military road around 1803. The Southwest Trail connected St. Louis, Missouri with Texas by steamboat in Fulton, Arkansas. The main railroad was built along the Southwest Trail, which developed many towns along the route. President Andrew Jackson appropriated money for the route in 1831, and designated it as a National Road. Although the route shifted slightly, it always has followed the natural break between the Ozark Mountains and the Ouachita Mountains.

Money for road maintenance was raised individually by county in the early 20th century, which hindered development of the route. In the 1920s, federal money became available, and the route was designated U.S. Route 67. The routing followed the Lakes to Gulf Highway and the Bankhead Highway. Federal designation brought paving to the route, which grew the small towns along the route.

In early 2009, the Arkansas legislature passed a bill naming the portion of US-67 from the Missouri state line to Jackson County "Rock n' Roll U.S. 67" as a tribute to the route that many musicians of the 1950s and 1960s took as they traveled. Governor Mike Beebe stated that he had hopes that the naming would bring tourism to northeast Arkansas. Porton of the route, and also Arkansas Highway 7 between Hope and Hot Springs frequently used by Bill Clinton is designated The Highway of Hope by Arkansas Code § 27-67-220.

AHTD is upgrading U.S 67 to a four lane highway. northeast of Little Rock. As of 2013, it runs as a Interstate-standard freeway to Highway 226 between Cash and Swifton. Construction is underway to extend the freeway to the U.S. 63 Bypass in the Walnut Ridge–Hoxie area, connecting to a pre-existing short section of U.S. 67 freeway that ends at U.S. Route 412. Long-range plans had called for the freeway to be extended from U.S. Route 412 to the Missouri State line, but Missouri backed off it's commitment to continue the freeway north of the state line. As a result, U.S 67 will only become an an expressway north of Walnut Ridge.