U.S. Route 60 is an east–west United States highway within Arizona. The highway runs for 369 miles (594 km) from a junction with Interstate 10 near Quartzsite to the New Mexico State Line near Springerville. As it crosses the state, US 60 overlaps at various points: I-17, I-10, SR 77, SR 260, US 191, and US 180.

The western terminus of US 60 is located at an interchange with I-10 east of Quartzite. It heads northeast from this junction to Vicksburg Junction where it curves towards the east. It continues to the east to Hope where it intersects SR 72. East of Hope, the highway briefly curves towards the north-northeast before curving towards the northeast. It continues this heading until it reaches Aguila. The highway heads east to an intersection with SR 71 after passing through Aguila. US 60 continues towards the east until it reaches Wickenburg and an intersection with US 93. From Wickenburg, the highway heads towards the southeast towards Phoenix. It has an intersection with SR 74 in Morristown as it continues towards the southeast.

As US 60 enters the Phoenix metropolitan area, it carries the name Grand Avenue and cuts a diagonal path through the northwestern part of the metropolitan area. It intersects Loop 303 in Surprise as it continues to the southeast. It continues to a junction with Loop 101 in Peoria before heading through Glendale. The highway enters the Phoenix city limits and continues towards the southeast until it reaches Thomas Road. US 60 follows Thomas Road for 1/4 mile until it reaches I-17. At I-17 the highway begins to run concurrently with I-17 towards the south. It passes I-10 interchange known as The Stack. US 60 continues to run concurrent with I-17 around the Durango Curve and continues east until it reaches the I-10 interchange known as The Split. US 60 begins to run concurrently towards the east with I-10 after the interchange. I-10 and US 60 continue towards the southeast after the interchange. The freeway passes along the south side of the airport and passes over a bridge over the Salt River. Once over the river, the freeway continues towards the east through Tempe to an interchange with SR 143. The freeway curves back towards the south following the SR 143 interchange.

As of 2006, Lower Grand Avenue near 7th Avenue and more specifically between Roosevelt Street on the north and Van Buren on the south, has been experiencing a quiet renaissance, as Independent Art Venues, Bars, Cafes and Small Businesses have emerged amid the work being done to restore the historical and landmark storefront properties that line the street filling the historic warehouses and other architecturally unique buildings.

On the "First Friday" and Third Friday's of every month, Grand Avenue comes alive with hundreds of Urbanites both young and old and suburban sprawlers clamoring for a cultural experience near the core of downtown Phoenix. Some of the outstanding galleries and art venues associated with the Grand Avenue art scene include: The Trunk Space, The Lodge Art Parlor, [ShopDevious.Com], The Icon Gallery, The Chocolate Factory, The Paisley Violin, The La Melgosa Complex: Deus Ex Machina, Phoenix Fall Space, Stop n' Look & Comet's Corner, The Annex: Soul Invictus, The Lucky Rabbit & Gallery Marsiglia, Lady Luck Tattoo, & many design houses and studios .

As a result of this urban growth and revitalization GAMA: The Grand Avenue Merchants Association, headed by Beatrice Moore, formed to address a "Grand New Vision" and to bring the Grand Avenue community together with other neighborhood associations to form a vibrant arts, culture and small business district with a mind towards adaptive reuse of historical buildings, responsible infill projects and both small business and community based outreach. Part of this vision, included a proposal commissioned by GAMA, for the historic Desert Sun site by building designer Effie Bouras, which was presented to City Council.

Improvements to Grand Avenue (North of the Interstate 10 Papago Freeway) are included in the 20-year Regional Transportation Plan of the Maricopa Association of Governments, including reducing many of the busiest three-way intersections to two-way intersections by constructing overpasses, underpasses, and access roads. In the future, it may be constructed to freeway grade.

After the curve, I-10 and US 60 part ways with I-10 continuing towards the south and US 60 now heading east along the Superstition Freeway. The freeway continues towards the east to a second interchange with Loop 101. The freeway enters the Mesa city limits after the interchange as it continues towards the east to the SuperRedTan interchange with Loop 202. The freeway enters the city limits of Apache Junction in Pinal County as it continues eastbound. The freeway portion of the highway ends in Apache Junction as US 60 curves towards the southeast.

The highway continues towards the southeast passing through Gold Canyon to an interchange with SR 79 at Florence Junction. US 60 curves towards the east at this junction as it heads to Superior and an intersection with SR 177. From Superior the highway begins to head towards the northeast to Miami and Claypool. It continues to a junction with SR 188 before passing through Midland City and turning towards the south towards Globe. US 60 curves back towards the east in Globe and continues to an intersection with US 70 and SR 77. US 60 heads northeast from the intersection concurrent with SR 77. The two highways curve towards the north before curving back towards the northeast as they head towards Show Low. As the highway continues towards the northeast it enters the San Carlos Indian Reservation. Within the reservation, the highway goes through a series of hairpin turns as it enters the Salt River Canyon. After descending into the canyon, the highway passes over the Salt River and enters the Fort Apache Indian Reservation. The highway continues towards the northeast and enters Navajo County before reaching an intersection with SR 73. It continues northeast from this intersection to the city of Show Low.

In Show Low, US 60 intersects SR 260 and briefly runs concurrently with SR 260 as it heads northeast through the city. The concurrency with SR 77 also ends in Show Low as SR 77 heads north to Snowflake and US 60 continues towards the east. US 60 leaves the Show Low city limits and heads east to a junction with SR 61 which heads northeast towards Concho. US 60 continues east from this intersection before curving towards the southeast as it heads towards Springerville.

As it enters the Springerville city limits, it intersects and begins to run concurrently with US 180 and US 191. The three highways continue along the same alignment through Springerville, passing over the Little Colorado River. As the three highways continue through the city, they eventually split with US 180 and US 191 heading south towards Alpine and US 60 continuing towards the east. US 60 continues towards the east leaving the Springerville city limits and crossing over the state line into New Mexico.

US 60 was extended into Arizona in 1932, from its original western terminus at US 66 in Springfield, MO. US 60 through Arizona has had far fewer major changes than some other U.S. routes, but one notable example is being replaced by Interstate 10 between Los Angeles, CA and the highway's current terminus near Quartzsite. US 60 is now the only US Route to serve Phoenix. US 70 (decom. 1969), US 80 (decom. 1977) & US 89 (decom. 1992) have all been truncated outside of Phoenix. The only other major change was being realigned from an "In-Town" route along city arterials through Mesa, Tempe, and Phoenix to the old SR 360 alignment a few miles south and merging with I-10 and I-17 into Downtown Phoenix.

In 1949, the Pinto Creek Bridge won an Annual Award of Merit for being the "most beautiful steel bridge", given by the American Institute of Steel Construction.

In 1952, the Claypool Tunnel was bypassed by the Queen Creek Tunnel, upgrading from a simple 'hole in the rock' type tunnel to a more modern tunnel.

In recent years, Arizona Department of Transportation (ADOT) has been working to widen and improve US 60 through the Metropolitan Phoenix Area, as it is one of the area's principal freeways. Along the Superstition Freeway segment in the East Valley between I-10 and Loop 202, ADOT has completed its project of adding additional general purpose lanes (6 total plus an HOV in each direction), adding auxiliary lanes between exits, improving sound barriers, replacing signs, improving lighting conditions, adding rubberized asphalt to reduce noise, adding variable message signs, installing cameras, and adding traffic sensors.

Along the Grand Avenue segment in Phoenix, ADOT has been widening portions of Grand Avenue in addition to constructing additional overpasses and underpasses at six former six-way intersections to improve traffic flow along US 60 in the Northwest Valley. ADOT is currently in the study phase of adding additional lanes between Loop 101 and Loop 303 in the far West Valley.

The portion of Grand Avenue in Phoenix between I-17 and I-10 that used to carry the US 60 designation is now known as unsigned U.S. Route 60X by ADOT.

Due to rapid growth in the far eastern Phoenix suburbs within Pinal County and increasing road congestion in the Gold Canyon area, ADOT has begun to study potential freeway-grade realignments of US 60 past the current eastern terminus of the Superstition Freeway in Apache Junction. The new freeway alignment would bypass the existing at-grade section of US 60 through Gold Canyon, and would either rejoin the existing alignment southeast of town (in the vicinity of the Arizona Renaissance Festival grounds) or at the newly-constructed freeway-grade junction with SR 79 at Florence Junction. This new alignment could also potentially serve as the northern terminus of the Pinal North-South Freeway.

Only the portion of US 60 east of the I-10 interchange has exit numbers, except for few old exits on the lower section of Grand Avenue. Most exits are not signed past Exit 200. All other segments are standard divided or undivided highways with uncontrolled access. The mileposts were not renumbered after the western leg was truncated, so they begin at milepost 30.89.