U.S. Route 19 in Georgia runs 348 miles (560 km) through Georgia from the Florida border south of Thomasville, Georgia—through Atlanta—to the North Carolina border at a point north of Nottely Lake, Georgia.

From the north side of the state, the first town it passes through is Blairsville. After about 37 miles (60 km) of extremely curvy road, it arrives in Dahlonega, where it becomes concurrent with Georgia 400. Most of this section is a limited access highway with 2 lanes in each direction, becoming 4-lanes in each direction as the highway travels through the northern suburbs of Atlanta.

At the junction with I-285's north side, it suddenly switches to become concurrent with State Route 9 (Roswell Road), about 1.5 miles (2.4 km) west. It follows Roswell Road south through the city of Sandy Springs and enters Atlanta from the north side of the city. After several miles, it intersects with Georgia 141 in Buckhead. This is also where Roswell Road ends and becomes Peachtree Street. After continuing south on Peachtree Street, it becomes Spring Street in Midtown. It turns west onto 14th Street for a few miles and then turns south again and becomes concurrent with U.S. Route 41 through Downtown Atlanta.

Once it leaves Atlanta, it continues south through Clayton County where it joins Georgia State Route 3 and is known as Tara Boulevard. It then proceeds through the western tip of Henry County, passing through Hampton, home of the Atlanta Motor Speedway. It then proceeds south to Griffin and splits from US 41. It continues south, passing through Zebulon, Thomaston, Ellaville, Americus, and Albany before exiting Georgia just south of Thomasville.

In 2006 business and government officials in Columbus began a campaign to have I-185 extended to Monticello, Florida, and connect with Interstate 10. The proposed route would run parallel S.R. 520 (known as Corridor Z) to Albany, and then parallel to U.S. Route 19.