Interstate 164 (I-164) is a spur highway of Interstate 64 in Evansville, Indiana. Interstate 164, also known as the Robert D. Orr Highway, has a total length of 21.24 miles (34.18 km). Requested as an interstate and approved in 1968, the highway was completed in 1991.

The highway is signed north-south as it wraps around the east side of the city and then east-west as it leads to U.S. Route 41. After intersecting with U.S. Route 41, the highway turns into the Veterans Memorial Parkway and provides a direct connection to the downtown business district.

A planned extension of Interstate 69 will utilize much of the existing route of Interstate 164 and eventually create a new international trade corridor from Canada to the Rio Grande Valley. The north end of I-164 connects with the new southern Indiana portion of I-69. Most of I-164, from its northern terminus at I-64/I-69 to a point approximately 1.5 miles (2.4 km) east of U.S. 41, will be eventually designated as I-69. I-69 will continue across the Ohio River on a new bridge heading southward from the present I-164. The state of Indiana has not stated whether the I-164 designation will continue to be used or whether the section of I-164 that will not become part of I-69 will be renamed as a spur route of I-69.