U.S. Route 50 in West Virginia runs from the border with Ohio to Virginia, passing briefly through Garrett County, Maryland, and following the Northwestern Turnpike. Prior to the U.S. Highway System it was West Virginia Route 1 and in the 1930s, the road was not finished in Maryland. At that time, motorists had to open a gate at the state line and drive on a dirt path until again reaching the other state line.[citation needed] Today the section of US 50 from Clarksburg to Parkersburg on the Ohio River is part of Corridor D of the Appalachian Development Highway System.

For much of its length, Route 50 roughly parallels the North Bend Rail Trail and crosses the trail at three places.