At only 1.062 miles (1.71 km) in length, Interstate 375 (I-375) in Detroit has the distinction of being the shortest signed Interstate Highway that is up to Interstate Standards. Only I-110 and the unsigned I-878 and I-315 are shorter. I-375 is the southernmost leg of the Walter P. Chrysler Freeway. It is a spur off of I-75 into downtown Detroit to end at the unsigned Business Spur Interstate 375 (BS I-375), better known as Jefferson Avenue. The freeway opened on June 12, 1964.

I-375 and the Chrysler Freeway begin at Jefferson Avenue and St. Antoine Street in downtown Detroit near the Renaissance Center. They run east before turning north. Just about a mile (1.6 km) after the southern terminus, I-375 meets the Fisher Freeway which carries I-75 north of downtown. At this interchange, I-75 takes ramps to leave the Fisher Freeway and use the Chrysler Freeway, replacing I-375. I-375 is a four-lane freeway the entire length. The entire length of I-375 is included on the National Highway System, a network of roadways that are the country's most important roads.

According to the Michigan Department of Transportation (MDOT), I-375 is 1.062 miles (1.709 km). Based on FHWA data, there are three Interstates that are shorter: I-110 in Texas (0.92 miles, 1.48 km), I-878 in New York (0.70 miles, 1.13 km) and I-315 in Montana (0.83 miles, 1.34 km). The latter two designations are not signed on their respective roadways.

Every year, MDOT conducts a series of surveys on its highways in the state to measure traffic volume. This is expressed in terms of average annual daily traffic (AADT), which is a measure of traffic volume for any average day of the year. In 2009, MDOT calculated that 14,112 vehicles per day used the southernmost section of I-375, and 53,900 vehicles used the northernmost section near I-75. These vehicles included 798 trucks.

Construction on the first segments of the Chrysler Freeway started on January 30, 1959. These segments were opened to traffic on June 26, 1964. The southern most segment was designated I-375 at this time.

The entire highway is in Detroit, Wayne County. All exits are unnumbered.

The unsigned Business Spur Interstate 375 (BS I-375), which is 0.167 miles (0.269 km) long, continues west on Jefferson Avenue from the southern end of I-375, ending at the entrance to the Detroit–Windsor Tunnel at Randolph Street (M-3). Jefferson Avenue past that intersection is M-10, quickly becoming the Lodge Freeway. BS I-375 runs next to the Renaissance Center and under a segment of the People Mover. This designation was created in 1964. The 2009 traffic surveys by MDOT reported that 33,376 vehicles, including 922 trucks, had used BS I-375.