U.S. Route 63 (US 63) is a highway in southeastern Minnesota that runs from the Minnesota-Iowa border south of Spring Valley to the Mississippi River at Red Wing. It connects the cities of Spring Valley, Stewartville, Rochester, and Lake City.

The route in Minnesota is 92 miles (148 km) in length.

U.S. 63 enters the state in Fillmore County, just north of Chester, Iowa. It travels north to Spring Valley where it becomes concurrent with State Highway 16, following it west for five miles entering Mower County. It continues north through Racine, then into Stewartville, after passing into Olmsted County, where it becomes a divided highway. Immediately after Stewartville, it intersects Interstate 90. The highway then enters Rochester 1 mile after the I-90 junction, where it is an expressway south of U.S. 52 (slowly becoming a freeway). After the intersection with highway 52, it becomes Broadway Avenue through downtown Rochester.

The highway is reduced to two lanes on the north side of Rochester and continues north through Olmsted and Wabasha counties. It meets U.S. Highway 61 at Lake City and overlaps it into the city of Red Wing. U.S. 63 turns southeast on State Highway 58 for one block and then turns northeast on 3rd Street. It then curves back northwest to cross over 61, and then reaches the Red Wing Bridge where it crosses the Mississippi River and enters the state of Wisconsin.

Nearly all of the route is legally defined as Constitutional Route 59 in the Minnesota Statutes, except for the part between Red Wing and the Mississippi River, which is Legislative Route 161.

U.S. 63 was extended into Minnesota in 1934. The route had previously been marked the year before as U.S. 59, except for the segment running from U.S. 61 to the river crossing, which had been State Highway 58. U.S. 63 was an original 1926 U.S. Route and terminated in Des Moines, Iowa until it was extended north. The U.S. 59 designation was simultaneously re-assigned to a new highway running from Laredo, Texas to Pembina, North Dakota.

The route was paved when it was marked.

In 2013, Highway 63 will be rerouted to avoid downtown Rochester. It will follow Olmsted County Road 14 to Highway 52. Highway 63 will be concurrent with Highway 52 through western Rochester, until the S Broadway exit on the southern side of the city.

The Minnesota Department of Transportation also has plans to turn Highway 63 into an controlled-access freeway between U.S. 52 and Interstate 90.