NC 751 is a north–south state road in North Carolina that runs from Business U.S. 70 in Durham to an intersection with U.S. 64 near the town of New Hill and Jordan Lake State Park. The road continues south approximately 4.3 miles (6.9 km) to U.S. 1 as New Hill-Olive Chapel Road, although it is not signed as N.C. 751, is shown on some maps. It runs largely parallel to N.C. 55, extending farther west towards Hillsborough which can be reached by continuing on U.S. 70.

N.C. 751 is a route formed early during the creation of the North Carolina route system. The original system established primary routes with two digit numbers and spurs with an extra digit at the end. N.C. 751 then was the first spur off of NC 75 which ran along the basic route of today's U.S. 15 and was supplanted by it, and then also by U.S. 501 in the late 1920s. N.C. 751's first routing took it from N.C. 75 (Old Chapel Hill Road in Durham) to N.C. 10, which is now U.S. 70. In the 1950s with U.S. 15-501 put onto a new route to the north, N.C. 751 was extended along Chapel Hill Street (now University Drive) and south along Hope Valley Road to N.C. 54. Later it was extended further south to U.S. 64.