Interstate 180 (abbreviated I-180) is a short spur highway linking Interstate 80 in Lincoln, Nebraska with downtown Lincoln. The length of the highway is 3.47 miles (5.58 km). It connects 9th and 10th Streets (a pair of one-way streets) to Exit 401 of Interstate 80. It overlaps U.S. Route 34 (US-34) for its entire length.

Interstate 180 begins in downtown Lincoln as a four-lane freeway, heading north concurrent with US-34. From the south end of the freeway, US-34 heads south on a one-way pair consisting of North 9th Street southbound and North 10th Street southbound. At the southern terminus, I-180 has a northbound exit and southbound entrance with North 10th Street that serves the University of Nebraska-Lincoln campus. The road passes over a Union Pacific/BNSF railroad line as it heads north between Haymarket Park to the west and residential areas to the east. I-180 crosses the Salt Creek and passes under US-6 before coming to a partial cloverleaf interchange with Cornhusker Highway that provides access to US-6. From this point, the freeway passes through more residential neighborhoods before coming to the Superior Street exit. A short distance later, I-180 reaches a cloverleaf interchange with I-80/US-77, where I-180 ends and US-34 continues to the west as a four-lane divided surface road called the Purple Heart Highway.

The entire route is in Lincoln, Lancaster County.